Dronedarone Hydrocholoride
Dronedarone hydrochloride
CAS: 141625-93-6
Molecular Formula: C31H44N2O5S.ClH
Dronedarone Hydrocholoride - Names and Identifiers
| Name | Dronedarone hydrochloride |
| Synonyms | CS-132 Multaq SR-33589B Dronedarone HCl Dronedarone hydrochloride Dronedarone Hydrocholoride Dronedarone Intermediate 1 N-[2-butyl-3-[4-(3-dibutyl-aminopropoxy) benzoyl] methanesulfonamide hydrochloride N-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-benzofuran-5-yl)methanesulfonamide hydrochlorid |
| CAS | 141625-93-6 |
| EINECS | 630-355-2 |
| InChI | InChI=1/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3;/h13-18,23,32H,5-12,19-22H2,1-4H3;1H |
| InChIKey | DWKVCQXJYURSIQ-UHFFFAOYSA-N |
Dronedarone Hydrocholoride - Physico-chemical Properties
| Molecular Formula | C31H44N2O5S.ClH |
| Molar Mass | 593.224 |
| Melting Point | NA (low-melting) |
| Boling Point | 683.9°C at 760 mmHg |
| Flash Point | 367.4°C |
| Solubility | DMSO: soluble15mg/mL, clear |
| Vapor Presure | 1.47E-18mmHg at 25°C |
| Appearance | White to white-like powder |
| Color | white to off-white |
| Merck | 14,3449 |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
| MDL | MFCD00914940 |
| In vitro study | In Purkinje fibers, Dronedarone decreased the early and delayed depolarization induced by 1 mM Dofetilide and 0.2 mM Strophantidine. In ventricular myocytes, Dronedarone(10 mM) significantly reduced L-type calcium currents (76.5%) and delayed rectifier potassium currents (97%). [1] In single cells isolated from the sinoatrial node (SAN) of the Rabbit Heart, Dronedarone inhibits I(K(ACh)) by reducing the channel opening probability (from 0.56 to 0.11) channel cell attachment without changing the single channel conductance. [2] In guinea pig ventricular myocytes, when the holding potential is -80 mV, Dronedarone state-dependent inhibition of fast Na(+) channel current, IC50 is 0.7 μm. At, Dronedarone blocked the -40 mV rectangular pulse-induced calcium ion current with an IC50 value of 0.4 μm, while at a holding potential of -80 mV, Dronedarone (10 μm) only 20% of the current is blocked. [3] |
| In vivo study | In the rat normal heart, Dronedarone increases the action potential duration. Dronedarone reduces the late sustained K() current, I(K)(or ISUS) by 69%. Dronedarone induced tonic blockade of I(K). In rats with myocardial infarction, Dronedarone induced a weak increase in fast transient outward currents. [4] |
Dronedarone Hydrocholoride - Risk and Safety
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| HS Code | 2935904000 |
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View History
Dronedarone Hydrocholoride
Dialuminum triselenide
D-GLYCERINE
NAPHTHENIC ACID LEAD SALT
FS SAMQA-6Z
FEMA No. 3394
氟化钠
so4-so4
(2S)-2-hydroxybutanedioic acid
Dialuminum triselenide
D-GLYCERINE
NAPHTHENIC ACID LEAD SALT
FS SAMQA-6Z
FEMA No. 3394
氟化钠
so4-so4
(2S)-2-hydroxybutanedioic acid